Frequently Asked Questions

Frequently asked questions (FAQs)

Here are some questions that people often have when facing non–small cell lung cancer (NSCLC) and considering treatment with RYBREVANT®. If you have questions about a specific word or term, check the glossary below.

About RYBREVANT®

RYBREVANT® is a targeted that works against . RYBREVANT® is different than chemotherapy, immunotherapy, and TKIs (tyrosine kinase inhibitors).

  • Learn about RYBREVANT® + LAZCLUZE (lazertinib) as a first treatment of NSCLC with exon 19 deletions or exon 21 L858R mutations here
  • Learn about RYBREVANT® + chemotherapy as a first treatment of NSCLC with EGFR exon 20 insertion mutations here
  • Learn about RYBREVANT® as a second treatment of NSCLC with EGFR exon 20 insertion mutations here

RYBREVANT® is an given into your vein through an IV () line. You’ll be given infusions at your doctor’s office or an infusion center. Your doctor will decide how many you will receive, the time between doses, and the appropriate dose of RYBREVANT® based on your body weight. Learn more about how RYBREVANT® is given and see the recommended infusion schedule.

  • Learn about RYBREVANT® + LAZCLUZE as a first treatment of NSCLC with exon 19 deletions or exon 21 L858R mutations here
  • Learn about RYBREVANT® + chemotherapy as a first treatment of NSCLC with EGFR exon 20 insertion mutations here
  • Learn about RYBREVANT® as a second treatment of NSCLC with EGFR exon 20 insertion mutations here

About mutations and biomarkers

RYBREVANT® is an antibody that targets EGFR mutations. To help determine if RYBREVANT® is right for you, your doctor may perform a . These tests can check your tumor for different , including EGFR, and can help guide your doctor to the appropriate treatment. Learn more about biomarkers here, and ask your doctor if an EGFR biomarker test is right for you.

A protein called an epidermal growth factor receptor (EGFR) is found on both normal cells and cancer cells. It drives cells to survive and grow. EGFR mutations may cause cancer cells to overgrow and spread to other parts of the body. Learn more about EGFR mutations here.

General questions

The 2 most common types of lung cancer are non–small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). The difference between these types is how the cancer cells look under a microscope and the different treatments approved for use for each. NSCLC is the most common type of lung cancer. About 80% to 85% of all lung cancer cases are NSCLC. Learn more about lung cancer here.

There are things you should know and do before you begin treatment with RYBREVANT®. Learn about the steps you can take to help you have the best possible treatment experience.

  • Learn how to prepare for RYBREVANT® + LAZCLUZE as a first treatment of NSCLC with exon 19 deletions or exon 21 L858R mutations here
  • Learn how to prepare for RYBREVANT® + chemotherapy as a first treatment of NSCLC with EGFR exon 20 insertion mutations here
  • Learn how to prepare for RYBREVANT® as a second treatment of NSCLC with EGFR exon 20 insertion mutations here

If you have any medical questions, you should always ask your doctor.

Once you and your doctor have decided that RYBREVANT® is right for you, sign up for RYBREVANT withMe support

RYBREVANT withMe: Personalized 1-on-1 Support

You have access to free, dedicated support. Your Care Navigator is here to help guide you to support solutions throughout your treatment journey, so you feel informed and empowered.

Starting a new medicine can be overwhelming, and you may still have questions. We are here to help.

Woman wearing headset offering support icon

Free 1-on-1 Dedicated Care Navigator Support

Piggy bank icon

Cost Support Options Regardless of Your Insurance Type

People support icon

Additional Resources and Community Connections

Sign up for personalized support throughout your treatment journey now by visiting RYBREVANTWithMe.com, or by calling 833-JNJ-wMe1 (833-565-9631), Monday through Friday, 8:00 AM – 8:00 PM ET.

Glossary

Glossary of common terms and phrases

Here are some questions that people often have when facing non–small cell lung cancer and considering treatment with RYBREVANT®. If you have questions about a specific word or term, check the glossary below.

Antibodies are protective proteins that help detect harmful substances and diseases such as cancers. They are made naturally by your immune system and can also be man made. Man-made antibodies used to treat cancer have a specific target on a cancer cell that they aim to find, attach to, and attack.

A biomarker is any molecule that can help show when your body is working normally or abnormally. This includes mutations in certain cells associated with advanced NSCLC.

A biomarker test identifies biomarkers by testing body tissue, blood, or other bodily fluids and can help your doctor determine which treatment is best for you.

Therapy that combines more than one method of treatment.

The amount of medicine given at one time.

The EGFR protein is involved in controlling cell division and survival. Sometimes, mutations (changes) in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer. This causes cancer cells to divide more rapidly.

One kind of EGFR mutation is called an "exon 20 insertion" mutation. While rare, exon 20 insertion mutations are the 3rd most frequent EGFR mutation in NSCLC, and can occur regardless of smoking history.

A method of putting fluids, including medicines, into the bloodstream through a vein.

The spread of cancer from the primary site (place where it started) to other places in the body. This can also be called “advanced” cancer.

Any change in the DNA sequence of a cell. Mutations may be caused by mistakes during cell division, or they may be caused by exposure to DNA-damaging agents in the environment. Certain mutations may lead to cancer or other diseases. A mutation is sometimes called a variant.

A result of a medicine that is separate or in addition to the medicine's use for treatment.

  • Learn more about the possible side effects of RYBREVANT® + LAZCLUZE here
  • Learn more about the possible side effects of RYBREVANT® + chemotherapy here
  • Learn more about the possible side effects of RYBREVANT® alone here
  • Something that a person feels or experiences that may indicate that they have a disease or condition. Some examples of symptoms are pain, nausea, fatigue, and anxiety.

    Savings & Support

    Once prescribed a RYBREVANT®-based treatment, connect with a Care Navigator for your support needs.

    See support provided

    Rybrevant with me