How RYBREVANT® (amivantamab-vmjw) Is Given
RYBREVANT® is given through an intravenous infusion under the attention of your care team
Your care team will create a treatment plan for you
Your care team will create a treatment plan for you
Your healthcare provider will decide the time between doses, as well as how many treatments you will receive. Your healthcare provider will also decide the appropriate dose of RYBREVANT® based on your body weight and give you medicines before each dose of RYBREVANT® to help reduce the risk of infusion-related reactions.
Before you receive RYBREVANT®, tell your healthcare provider about all of your medical conditions, including if you
- Have a history of lung or breathing problems
-
Are pregnant or plan to become pregnant. RYBREVANT® can harm your unborn baby
Females who are able to become pregnant:
- Your healthcare provider should do a pregnancy test before you start treatment with RYBREVANT®
- You should use effective birth control (contraception) during treatment and for 3 months after your final dose of RYBREVANT®
- Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with RYBREVANT®
- Are breastfeeding or plan to breastfeed. It is not known if RYBREVANT® passes into your breast milk. Do not breastfeed during treatment and for 3 months after your final dose of RYBREVANT®
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Infusion Schedules
Infusion schedule for RYBREVANT® + chemotherapy
RYBREVANT®
Chemotherapy
Week 1
Day 1
Day 2
- Your first dose of RYBREVANT® will be split across 2 days
- When you start treatment, you will be given 2 types of chemotherapy
- Your first RYBREVANT® infusions times may be 4-6 hours on Day 1 and 6-8 hours on Day 2
- Infusion times may get shorter as your treatment continues
Week 2
Week 3
- No chemotherapy is provided during Week 2 and Week 3 infusions
- RYBREVANT® infusions may take 3 to 4 hours
Week 4
- Week 4 includes chemotherapy
- After Week 4, you will receive infusions every 3 weeks
- RYBREVANT® infusions will take about 2 hours, starting on Week 4 and for the rest of treatment
Week 7
- RYBREVANT® dosage is adjusted on Week 7
- Your chemotherapy treatment remains the same
Week 10
- RYBREVANT® dosage and your chemotherapy treatment remain the same
Week 13 and on
- At Week 13, you will only be given 1 type of chemotherapy
- Following Week 13, your dosage and frequency will likely remain the same
- Your doctor will monitor your progress and adjust treatment accordingly until disease progression or unacceptable toxicity
Infusion schedule for RYBREVANT® alone
Your first dose will be given over 2 infusions and may be adjusted to help manage possible infusion-related reactions.
After your first dose (2 infusions), you’ll get 1 infusion each week for the next 4 weeks.
Starting on week 7, you will get 1 infusion every 2 weeks.
While everyone's experience is unique, infusion times may get shorter after your first dose.
- Your first dose (the infusion on Day 1 and Day 2) can take about 4 to 8 hours
- Subsequent infusions can take about 2 hours
Premedication
Your treatment team will give you medications before initiating your infusion to help reduce the risk of side effects during infusion
- The medicines can be an antihistamine, a fever reducer, and a steroid
- Premedication will likeIy be given 15 to 60 minutes before your infusion
Dosing modifications
Your healthcare provider may pause, decrease your dose, or completely stop your treatment, depending on your side effects
Keep your care team informed about how you’re feeling so they can adjust your treatment and find what works for you.
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