Sorry, you need to enable JavaScript to visit this website.

How RYBREVANT® is Administered | RYBREVANT® (amivantamab-vmjw)


How RYBREVANT® (amivantamab-vmjw) Is Given

RYBREVANT® is given through an intravenous infusion under the attention of your care team

Your care team will create a treatment plan for you

Infusion bag with medical cross

Your healthcare provider will decide the time between doses, as well as how many treatments you will receive. Your healthcare provider will also decide the appropriate dose of RYBREVANT® based on your body weight.

Before you receive RYBREVANT®, tell your healthcare provider about all of your medical conditions, including if you

  • Have a history of lung or breathing problems
  • Are pregnant or plan to become pregnant. RYBREVANT® can harm your unborn baby

    Females who are able to become pregnant:

    • Your healthcare provider should do a pregnancy test before you start treatment with RYBREVANT®
    • You should use effective birth control (contraception) during treatment and for 3 months after your final dose of RYBREVANT®
    • Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with RYBREVANT®
  • Are breastfeeding or plan to breastfeed. It is not known if RYBREVANT® passes into your breast milk. Do not breastfeed during treatment and for 3 months after your final dose of RYBREVANT®

Two pills

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Infusion Schedule

With RYBREVANT®, the dosing schedule may change and become less frequent after your first dose.


Your first dose will be given over 2 infusions and may be adjusted to help manage possible infusion-related reactions.


After your first dose (2 infusions), you’ll get one infusion each week for the next 4 weeks.


Then, you’ll get one infusion every 2 weeks.

While everyone's experience is unique, infusion times may get shorter after your first dose.

  • Without an infusion-related reaction (IRR):
    • Your first dose (the infusion on Day 1 and Day 2) can take about 4 to 6 hours
    • Infusions can get shorter starting on Week 2, and can take about 2 to 4 hours

However, your healthcare provider may interrupt or stop your infusion if an adverse reaction occurs.

Keep your care team informed about how you’re feeling so they can adjust your treatment and find what works for you.

dollor graphic

Concerned about cost?

There are cost support resources that can help.

Cost support

Register Updates

Register for Updates

Sign up to receive the latest news and information about RYBREVANT®

Register here